Composition, form of entry into the pharmaceutical market, manufacturer
Lokoid Lipokrem acts as a normal remedy that is used for various degrees of skin disorders. Used only as an external preparation. The work of the cream is to quickly relieve skin inflammation, swelling or relieve itching.
This is a good remedy at an affordable price, which is used as a medicine for treating the skin, with the exception of wounds and cracks.
Scope of application – treatment of skin diseases (various types of dermatitis, except bacterial, infectious; eczema, psoriasis).
It is considered a rare drug of its kind that contains a hormone. No signs of addiction were found. In a situation where there is no addiction, the body continues to function as usual, and relapses in the occurrence of rashes are not observed.
Manufacturer: European company AstellasPharmaEuropeB.V. Production plants are located in Italy and the Russian Federation.
There are several forms in which the medication is produced. It depends on the degree and neglect of the lesions:
- Ointment;
- Cream;
- Emulsion. It has its own name “Krelo”.
In the presented forms, the active element that is included in the composition is a hormone. It is contained in the same concentration.
The active element of the product is hydrocortisone 17-butyrate. Among the additional substances in the composition are:
- Vaseline oil;
- polyethylene;
- alcohol;
- paraffin;
- borage oil and others.
The product is placed in aluminum tubes with a total volume of 30 grams. You can buy it in pharmacies without a doctor's prescription. The shelf life is 3 years. Must be stored in a cool place, away from children. The cost ranges from 250 – 350 rubles.
Features of good stagnation
Do not apply the ointment to the eyelids because it may stain the conjunctiva and cause the risk of developing primary glaucoma or subcapsular cataracts.
The facial skin, genitals and scalp are most sensitive to corticosteroids. Thus, to treat illness in these plots, only weak corticosteroids can be used.
Sometimes you can completely apply a bandage to the affected area with access or without access, or put an occlusive bandage.
The effect of corticosteroids can be enhanced by applying an occlusive dressing due to increased penetration (with a coefficient of approximately 10) of the drug through the horny ball into the epidermis. However, there is a greater risk of side effects.
It is important to note that when corticosteroids are dried on large sections of the skin, especially in vikristan (cellophane) bandages or in the folds, there is a possibility of increased absorption of the drug, which may lead to and until adrenocortical function is suppressed.
Suppression of the measles of the epidermis can quickly develop in children. You may also experience growth hormone production. When long-term treatment is necessary, it is important to regularly monitor the growth and body mass of the child, as well as determine the level of cortisol in the blood plasma.
When conducting regular research, no significant changes in adrenocortical function were found in children who were treated with Locoid® ointment or hydrocortisone 1% for 4 days in a quantity of 30–60 grams for a week.
If the drug is applied to a plot of skin, then applied to other plots of thin skin, it can lead to atrophy of the skin and increased absorption of the drug.
Corticosteroids for local congestion may not be safe for patients with psoriasis due to low reasons, including “rebound syndrome” due to the development of tolerance, risk of development of generalized pustular psoriasis, and myocardial infarction. skin systemic toxicity due to impaired barrier function of the skin. Steroids can be used for psoriasis of the scalp and chronic psoriasis of the hands and feet. It is important to carefully watch out for the sick.
Destroyed dawn.
With systemic and local ingestion of corticosteroids, vision impairment may occur. If the patient exhibits symptoms such as blurred vision or other vision impairment, consult an ophthalmologist to evaluate possible causes, which may include cataracts, glaucoma or rare diseases, such as central serous chorioretinopathy (CSC), which was reported later systemic or local constipation of corticosteroids.
Suspension during pregnancy or breastfeeding.
Vaginism.
Corticosteroids cross the placenta. There is now clear information about the development of teratogenic effects in humans, similar to those that were observed in animal studies. Local stagnation of corticosteroids in vaginal animals in high doses may cause problems in the development of the fetus, such as splitting of the hard palate and obstruction of intrauterine development. Moreover, these pre-clinical studies do not provide conclusive information until the drug has clearly been stagnated in clinical practice.
With systemic administration of large doses of corticosteroids, influx into the fetus or newborn was reported (inhibition of fetal growth, adrenocortical suppression).
Regardless of the small amount of information, the accumulation of corticosteroids on the skin of the vaginal woman, looking at it, is surrounded by systemic absorption, the possible accumulation of corticosteroids is weak and dying. ii (class 1 and class 2), such as hydrocortisone, for short periods of time and on the skin area. The obvious effects cannot be turned off when the skins have been cured or applied to large sections of skin. You can be more careful if special indications are evident.
Goddamn breastfeeding.
Lokoid®, an ointment, can be applied to women who are breastfeeding without just a short bath and application to small areas of the skin. With a long-term treatment or applied to large areas or on the affected skin, apply a bath to the chest.
This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.
Daily data on the use of Lokoid® ointment injected into the body by vehicles or other mechanisms. Viniknennya is not overflowing.
pharmachologic effect
Each of the drug release forms has a long-lasting effect. Can be used only externally by lubricating the affected areas.
Hydrocortisone is the element that can have a good effect on inflammation, relieving swelling and itching of the skin. The medication does not activate addiction processes, and after stopping its use, the body quickly establishes the formation of natural hormones.
The active substance penetrates inside and accumulates in its upper layer, then enters the bloodstream. Part of the hormone that enters the blood is dissolved in the liver.
Contraindicated
- Skin damage caused by bacterial infections (for example, pyoderma, syphilitic or tuberculous infections), viral infections (for example, chickenpox, herpes simplex, surgical herpes, primary wart, flat wart, condyloma, molluscum contagiosum); infections caused by fungi and yeasts; parasitic infections (such as scabs);
- virulence of the skin, wounds;
- adverse reactions caused by corticosteroids (such as oral dermatitis, striae);
- ichthyosis, juvenile plantar dermatosis, acne vulgaris, rosacea, laxity of the skin vessels, skin atrophy;
- allergic reactions of hypersensitivity to the components of the drug or corticosteroids (the others rarely occur).
Instructions for use
Used topically. The instructions look like this:
- clean the area of skin where the product is applied;
- The medicine must be applied in a thin layer. Repeat the procedure no more than four times a day.
Doctors recommend following a course of treatment for a total duration of three weeks.
The volume of the drug per week does not exceed 30 grams.
In case of problems with peeling skin around the anus, you must:
1. Clean your hands and treat the affected area with soap and water. Then follow the doctor's instructions.
In the presence of weeping wounds, as well as treatment of the scalp, lotion and emulsion are used.
If there is no visible effect, it is possible to apply a bandage with the product to the wound to exaggerate the effect. If signs of deterioration appear, treatment should be stopped.
When using Lokoid Lipocrem in cream form, you must avoid getting the product into your eyes. If this happens, rinse the damaged areas under running water.
Lokoid cream for external use 0.1% 30g tube
If there are signs of hypersensitivity or skin irritation associated with the use of the drug, you should stop treatment and consult a doctor. With prolonged treatment, when applying the drug to large surfaces of the skin, when using occlusive dressings, as well as in children, systemic absorption of the glucocorticosteroid is possible; it is possible to suppress the function of the hypothalamic-pituitary-adrenal system and develop symptoms of hypercortisolism.
Atrophic changes may appear on the skin of the face more often than on other surfaces of the body after long-term treatment with topical glucocorticosteroids; the course of treatment in this case should not exceed 5 days.
Care must be taken when applying the drug to the face, folds, natural folds, and areas with thin skin.
Avoid getting the drug into your eyes. Do not apply the drug to mucous membranes.
It should be borne in mind that glucocorticosteroids can change the manifestations of some skin diseases, which can make diagnosis difficult. In addition, the use of glucocorticosteroids may delay wound healing.
With long-term therapy with glucocorticosteroids, sudden cessation of therapy can lead to the development of rebound syndrome, manifested in the form of dermatitis with intense redness of the skin and a burning sensation. Therefore, after long-term treatment, drug withdrawal should be carried out gradually, for example, by switching to an intermittent treatment regimen before stopping it completely.
Cetostearyl alcohol, which is part of the drug, may cause irritation at the site of application.
Propyl parahydroxybenzoate may cause allergic reactions (possibly delayed). In such cases, you should stop using the drug.
Use in pediatrics The drug Lokoid® can be used in children from 6 months. It must be taken into account that in young children, skin folds, diapers, and diapers can have an effect similar to the effect of an occlusive dressing and increase the systemic resorption of glucocorticosteroids.
In addition, in children, a greater degree of systemic resorption is possible due to the relationship between the surface of the skin and body weight, as well as due to insufficient skin maturity. Long-term treatment of children with glucocorticosteroids can lead to disturbances in their growth and development. Therefore, long-term use of the drug should be carried out under the supervision of a physician.
Children should receive the minimum dose of the drug sufficient to achieve the effect.
In children, the course of treatment should not exceed 7 days.
Effect on the ability to drive vehicles and operate machinery There is no data on the effect of the drug Lokoid® on the ability to drive vehicles and operate machinery.
Contraindications
Contraindications for use include:
- for dermatitis, healing, which is complicated by infections of various spectrum;
- in the presence of wounds and cuts at the site of direct treatment;
- rosacea;
- oral dermatitis;
- acne;
- dizziness;
- sleep disturbance;
- disruption of the menstrual cycle in women;
- convulsions;
- the period of vaccination of the patient;
- during pregnancy and lactation, use with caution under the supervision of the attending physician;
- Children are no earlier than six months old.
Indications for use
Ointments, lotions and Lokoid cream should be used according to the instructions in the treatment of the following dermatological pathologies:
- psoriasis;
- eczema;
- depriving;
- seborrhea;
- dermatitis of various etiologies;
- Other skin diseases accompanied by itching, swelling, inflammation.
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Positive and negative sides
The positive aspects of the funds are:
- efficiency;
- fast and noticeable results;
- the ability to select options for funds;
- lack of examples of addiction to the components of Lokoid Lipokrem.
Flaws:
- a large number of contraindications and side effects;
- price;
- is a hormone, which frightens many patients.
Release form and composition
Lokoid is an ointment with a uniform fatty consistency, white or grayish in color. Contained in a sealed aluminum tube. Weight – 30g.
Lokoid ointment - hormonal or not - is a question of interest to many, because the drug is on the market.
The drug contains the only active ingredient - hydrocortisone 17-butyrate, which is a glucocorticosteroid, that is, a hormone. Its content is 1 mg/g, which is 0.1%.
The fatty base is Vaseline and polyethylene.
Analogs
Lokoid Lipokrem has several types of analogues. Among them are the following:
- Afloderm;
- Dermovate;
- Cloveit;
- Fluorocort.
Has a synonym drug. It's called Laticort. It is also available in three types, like Lokoid Lipocrem. It is considered a synonym because it contains the same hormone.
Comparative analysis of Lokoid Lipokrem and its analogues
Hydrocortisone ointment
In the question of what is better to use, pure hydrocortisone in the form of an ointment or Lokoid Lipokrem, you need to understand what common features and differences they have.
The main active ingredient is hydrocortisone. Both medications are hormonal. Sold in pharmacies without a doctor's prescription. Scope of action: relieving inflammation, preventing itching.
Differences:
- The presence of additional substances in the composition of Lokoid Lipokrem.
- Differences in release forms. Hydrocortisone is sold only as an ointment.
- Price. Hydrocortisone ointment can be bought at a price of 30-70 rubles, and Lipocrem 300-500 rubles;
- Hydrocortisone ointment is used to treat skin in children over two years of age. Lipocrem – after 6 months of birth.
Laticort
Both are hormonal medications and contain hydrocortisone. Used in the treatment of skin diseases, dermatitis, psoriasis. Identical release forms.
The differences are as follows:
- The country of origin of Lokoid Lipocrem is the Russian Federation and the Italian Republic. Laticort has Poland;
- Laticort has fewer contraindications;
- The cost of Laticort is more acceptable and is within the average price range for a drug of this type.
Brief characteristics of Lokoid in ointment form
The active ingredient in the ointment is the same as in the cream - glucocorticoid hormone, adapted for external use. However, since Lokoid ointment is fatty, in addition to the active ingredient, it contains only one excipient - petroleum jelly .
The indications and contraindications for the ointment are the same as for the cream, since these indicators are determined by the effects of the active substance.
Mode of application
The drug is applied to the skin 1-3 times a day . If there are good results, the frequency of use can be reduced to 2-3 times a week . The duration of treatment is determined by a dermatologist depending on the diagnosis and dynamics of the disease.
Side effects when using the ointment are the same as when using any other hormonal external preparations: in addition to possible skin irritation, there is a risk of developing atrophic changes.
Features of use in children and pregnant women
The use of Lokoid is possible in children, as well as in pregnant and lactating women. However, the use of the drug should be carried out under medical supervision and only with the recommendations of medical specialists.
The maximum duration of treatment with the drug for small children and pregnant women is no more than 10 days.
Lokoid ointment and analogues of this product, as well as cream and lotion, can cause side effects in the form of itching, dryness, burning, and dermatitis. Creams may accompany the development of menstrual irregularities, diabetes mellitus, stomach and duodenal ulcers, migraines, and seizures, but such manifestations are rare.
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