Diane-35 - instructions for use, doses, side effects, contraindications, price, where to buy

Hormonal Diane 35 is a pill with a double effect. They prevent unwanted pregnancy and at the same time treat acne, oily skin and hair, and baldness. In women, coarse hair on the face and body stops growing, menstrual function normalizes, and conception becomes possible after stopping use. Find out who is prescribed the drug, how long you can take the pills without a break, and why they are dangerous, read our article.

Composition and properties of the hormonal drug Diane

The tablets contain two substances. One of them is an analogue of the female sex hormone – ethinyl estradiol. The second component is cyproterone. It blocks the action of male steroids (androgens) by binding to their receptors. This is the name given to proteins on the cell membrane through which hormones exhibit their properties.

If the receptors have already connected with cyproterone, then androgens will not be able to affect the tissue. This leads to a decrease in sebum secretion and the gradual disappearance of acne. Hair also becomes less oily, and hair loss stops if it occurs due to hormonal imbalance. One of the important effects is to stop the growth of coarse hair on the face (like a mustache, sideburns, beard) and torso (belly, back), lower legs, and inner thighs.

Excess androgens in the blood are dangerous not only due to external changes. It also appears:

menstrual irregularities - delays, rare, scanty, possible breakthrough bleeding after absence;
ovulation does not occur, which means conception is impossible;
cysts form in the ovaries (polycystic syndrome), as the maturation of follicles stops;
body weight increases;
carbohydrate metabolism is disrupted - tissues become insensitive to insulin, and glucose circulates in increased quantities in the vessels;
the risk of heart disease increases due to changes in fat metabolism;
If there are a lot of male hormones in the blood for a long time, then this is a predisposing condition for uterine cancer.

While therapy aimed at reducing androgens is being carried out, pregnancy is prohibited. Hormonal tablets Diane 35 have a contraceptive effect, which eliminates the need to take other drugs for this purpose.

We recommend reading the article about obesity due to hormonal imbalance. From it you will learn what hormonal imbalance causes obesity, whether obesity occurs after hormonal pills, signs of changes in hormonal levels, as well as the diagnosis of hormonal imbalances and the treatment of this type of obesity.

And here is more information about vitamins for women’s hormonal levels.

Pharmacodynamics and pharmacokinetics

Diane-35 (reviews from women who took the drug indicate its positive effect on the body) is a hormonal drug that has a combined effect. Ethinyl estradiol is an estrogen, and cyproterone acetate is an antiandrogen with progestogenic activity.

The combined formula of these components makes it possible to treat diseases of the female body, the occurrence of which is provoked by androgens. Patients with acne, dermatitis or seborrhea of hormonal origin fully recover after 3-4 months. course of continuous therapy.

One of the pharmacodynamic properties of Diane-35 tablets is the direct effect of the drug on the functional state of the woman’s reproductive system. Throughout the entire period of drug therapy, the likelihood of conceiving a child is minimized.

The gestagenic effect of the drug excludes the possibility of fertilization of the uterus with sperm with further attachment of a viable embryo to the endometrial layer of the uterus. At the same time, the effect of reducing the likelihood of painful periods is achieved, and the amount of bleeding decreases.

The pharmacodynamics of the drug Diane-35 is characterized by the combined effect of cyproterone acetate and ethinyl estradiol. These 2 hormonal substances have different properties and mechanisms of influence on the functions of the reproductive and endocrine systems of the female body. After taking a single dose of Diane-35, cyproterone acetate is completely absorbed into the walls of the gastrointestinal tract and enters the general bloodstream.

The bioavailability of the active component is 88%, and its maximum concentration in the blood serum is achieved after 1.5 hours. Cyproterone acetate has good binding to albumin, but from 3.5 to 4% of this substance is in a free state. In lactating women, about 0.2% of a standard dose of this substance is excreted in breast milk.

The half-life of cyproterone acetate is divided into 2 phases. The breakdown of the hormonal substance to the state of metabolites lasts 8 hours. Complete removal of the biochemical substance products continues for 2-3 days from the moment of taking a single dose.

The biotransformation of cyproterone acetate occurs in liver tissue and includes its hydroxylation with the formation of the main metabolite in the form of a 15-beta-hydroxyl derivative. About 75% of the biochemical breakdown products of this component are excreted by the kidneys along with urine. The remaining 25% is eliminated from the body in feces.

The pharmacokinetics of ethinyl estradiol is characterized by rapid absorption and the presence of a primary stage of metabolism. After ingestion, this substance is absorbed into the intestinal walls and then evenly distributed throughout the body. As it passes through the liver tissue, ethinyl estradiol undergoes a stage of intense degradation with the formation of active metabolites.

In this regard, its bioavailability is low, amounting to no more than 45%, and also has individual variability. After taking 1 tablet of the drug, the maximum concentration of ethinyl estradiol in the blood plasma is reached after 1.5 hours.

Ethinyl estradiol has a significant effect on the functional state of the liver, increasing the synthesis of corticosteroid globulins in this organ. This component of the drug Diane-35 also has a two-phase half-life mechanism. The primary metabolism of ethinyl estradiol lasts from 1 to 2 hours, when the drug saturates the bloodstream and accumulates in the liver tissue.

At the 2nd half-life stage, the resulting half-life products are gradually eliminated, the duration of which is 20 hours (beta phase). Utilization of ethinyl estradiol metabolites is carried out by the kidneys and liver. About 40% of biochemical substances are excreted in the urine, and the rest in the feces.

Indications for use

Disorders that depend on the action of androgens can occur in different combinations. To prescribe this hormonal drug, one of the following symptoms is sufficient:

acne;
hair loss on the head;
increased growth of coarse hairs according to the male type (face, torso, limbs);
seborrhea – increased greasiness of the skin and hair.

Their treatment with Diane 35 will be effective only if a preliminary examination is carried out and the role of male sex hormones in their development is established.

pharmachologic effect

Mechanism of action of COCs
The drug Diane-35 is part of the group of combined oral contraceptives.

In addition to contraception, it has several other effects simultaneously on the female body :

Progestational.
Estrogenic.
Antiandrogenic.

Contraceptive effectiveness occurs due to the thickening of mucous secretions.
This makes it very difficult for sperm to travel to their intended goal, which is why pregnancy does not occur. Contraceptive Diane-35 with antiandrogenic effect. This is achieved due to the presence of cyproterone acetate.

The substance helps reduce or completely eliminate signs of a woman’s masculinization :

The secretion of subcutaneous lipids decreases.
Hair loss is reduced.
The growth of unwanted hair stops.

As a result of the intake process, some diseases that arose due to an excess of androgens are also eliminated. Thanks to the drug Diane-35, you can get rid of acne.

The contraceptive inhibits ovulation, making monthly bleeding less painful and intense. The menstrual cycle itself is regulated to a normal state.

Video on the topic:

How to drink during hormonal imbalance Diana 35

The package is designed for 21 days. Treatment should begin on day 1 of the cycle (menstruation). Then take 1 tablet every day at exactly the same time. After finishing the package, there should be menstrual bleeding - about 2-3 days. Regardless of its availability and duration, exactly 7 days later you need to start the next package.

Usually, if all conditions are met, the contraceptive effect occurs on 1 day of use. If a woman’s cycle is not regular, or she started using the pills from day 2 or later, then in the first week it is necessary to provide for the likelihood of conception.

Therefore, you need to use condoms and suppositories to prevent pregnancy. The same precautions are observed when switching from other methods of contraception (spiral, vaginal ring, patch).

If menstruation is absent for more than 1 cycle, then any day of admission is chosen, and then, in the same way, after 21 days a 7-day break is needed.

Is it possible to take pills without a break?

When the drug is taken for therapeutic purposes, you can expect an improvement in the condition of the skin after 3 cycles. Then you should definitely visit a gynecologist, who will conduct an examination, refer you for an ultrasound, blood tests for hormones, and a coagulogram (clotting).

If necessary, other examination methods may be recommended. Based on the data obtained, a conclusion is drawn about the possibility and advisability of further therapy.

Ultrasound of the pelvic organs

As a rule, acne and facial greasiness disappear first. Then hair growth on the head improves and stops on the face and body. This interval is individual for each patient. If after 6 months there are no positive results for the skin and 12 for the hair, then you need to change the treatment regimen.

If the therapy has a good effect, Diane 35 takes 4 more cycles, then, depending on the woman’s desire to have a child, they choose another contraceptive or stop using them completely.

Often, after the end of therapy, signs of excess hormones resume. This is because blocking the effects of androgens is not permanent.

If the source of hormonal synthesis (ovaries, adrenal glands) is not detected and appropriate treatment is not carried out, then the effect of Diane will be temporary. In the absence of contraindications, use of the drug can be resumed after discontinuation.

Based on clinical studies, it has been established that without health concerns you can take hormonal Diane without a break for 36 months. There is also experience of a longer course.

Contraindications

The drug is highly effective, but it has serious consequences when used. In order to avoid complications, it is important to undergo a full range of diagnostics before starting treatment. It includes:

ECG, rheography of the lower extremities;
blood test - general, biochemistry, glucose, cholesterol, human chorionic gonadotropin, coagulogram;
Ultrasound of the mammary glands, pelvic organs, liver;
cytology - smears from the vagina, cervix.

During the treatment period, studies are needed at least once every 6 months.

Diana is contraindicated for women:

in case of prescribing other hormonal contraceptive pills, some antiviral (for example, Ritonavir);
when the veins of the leg or arteries of the lungs are blocked by a thrombus (blood clot), or if close relatives or the patient herself have had such situations in the past;
those who have had a heart attack, stroke, or suffer from angina pectoris, cerebrovascular accidents or blockage of the leg arteries;
with a high risk of thrombosis due to diabetes, hypertension, high cholesterol, hereditary blood clotting disorders;

with detected sickle cell anemia;
with severe liver damage until its function normalizes;
if tumors were previously identified - both benign and cancerous;
with unknown origin of uterine bleeding
for migraines;
smoking;
during pregnancy, those who suffered from jaundice, itchy skin, herpes, and hearing loss;
before excluding pregnancy or when planning it;
during lactation.

One of the contraindications is the lactation period.
This drug is not prescribed to men, as well as women after menopause.

Contraindications for taking this drug

There are the following contraindications for using the drug:

thrombosis, acute or already treated;
cardiovascular diseases, heart attacks, angina pectoris, strokes, both acute and already treated;
diabetes mellitus of both types with vascular disorders;
diseases of the liver, gall bladder, hepatitis, cancer of the liver;
oncological diseases of the mammary glands, genital organs, acute or in remission;
uterine bleeding, the causes of which have not been determined;
pregnancy, lactation;
the presence of allergic reactions to the components of the drug.

At the first manifestations of illness or side effects, immediately stop taking the drug and consult a doctor to prescribe other treatment.

Remember that taking Diane 35 does not protect against HIV infection or sexually transmitted infections. Never offer the drug to other people if it was prescribed to you.

If you are pregnant, taking the drug may cause a miscarriage or the development of abnormalities in the fetus.
During lactation, taking the drug is prohibited due to the fact that loss of the ability to produce milk may occur, and the risk of mastopathy increases. Separately , it should be noted that the drug is not prescribed for children and adolescents, and it is also contraindicated after menopause.
Women with liver disease should not take the drug until clinical liver parameters return to normal. For women with kidney problems, the drug is most often not prescribed due to the fact that the effect of the drug has not been fully studied, and it is not known how the kidneys will react to it. For those women who smoke, the drug is not prescribed ; the combination of nicotine and medicinal components of Diane 35 can lead to the development of serious consequences, such as thrombosis or stroke.

Acne sulfur is one of the most popular cosmetic products. It has a mild bactericidal effect, which is why it is included in many medications.

Possible complications after hormonal Diana

The main risk of using the drug is the possibility of blockage of a vein or artery by a blood clot. It is also impossible to exclude the possibility of a tumor process in the cervix, mammary gland and liver. Therefore, it is important to undergo regular examinations throughout the course of therapy. Other afterwords include:

inability to use contact lenses to correct vision (the curvature of the cornea changes);
nausea, pain or discomfort in the intestines, diarrhea;
weight change (loss, increase);
swelling;
headache;
depressed mood;
decreased sex drive;
tension and pain in the mammary gland;
increased intensity of vaginal discharge;
bleeding between regular menstruation;
skin rashes, spots;
hypertension;
exacerbation of chronic pancreatitis.

Patients with diabetes mellitus, liver disease, epilepsy, depression and ulcerative colitis should be under medical supervision, as Diane 35 can worsen the course of these diseases. Some women develop brownish spots on their skin when exposed to the sun .

If there is no bleeding in the interval between taking a new package, pregnancy should always be ruled out.

Side effects from using Diane-35 for the treatment of pimples and acne

"Diane-35" is a hormonal drug, so all aggravating phenomena will be of a corresponding nature.

Regardless of the main purpose of use - it will be protection from unwanted pregnancy or treatment of skin rashes - the threat of deterioration of health is present. This applies to the body of even absolutely healthy women. When the concentration of hormones in the blood increases sharply, one should expect problems with the functional ability of internal organs, mental state, which will affect lifestyle or create the need to change the daily routine.

Common side effects from taking Diane-35:

1. Frequently recurring episodes of headache. 2. A feeling of heaviness in the parietal region and the back of the head, pulsation in the temples. 3. Dizziness. 4. Increased sensitivity of the mammary glands, swelling of the breasts, pain in the nipples. 5. The appearance of discharge from the mammary glands - the consistency of the secretion resembles colostrum, which is produced in the first trimester of pregnancy. 6. Weakening libido. 7. Feeling of constant fatigue, desire to rest more. 8. Instability of the psycho-emotional background, sudden mood swings. 9. Difficulties arise with the use of contact lenses - the mucous membrane of the eyes rejects this device, causing lacrimation and conjunctivitis. 10. Dyspeptic disorders develop - the woman feels sick, sometimes the attack ends with vomiting. 11. Vaginal discharge takes on a different character. 12. Additional skin inflammations appear. 13. A woman experiences peripheral edema - this phenomenon must be coupled with difficulties in the functioning of the kidneys. 14. The outflow of urine is delayed. 15. The sense of smell is heightened, the condition resembles a period of toxicosis, when primitive smells irritate and cause disgust. 16. Body weight is gained by at least 10%.

It is impossible to predict what reaction the body will have to taking the Diane-35 contraceptive, so before using the pills, you need to determine the state of your hormonal levels. Knowing the indicators of the hormonal panel, you can be sure that treating acne with this particular contraceptive is at least advisable. And most importantly, it will not harm the woman’s health. During treatment with Diane-35, you should not squeeze out the rash that appears or otherwise try to speed up the healing process of wounds if acne leads to them. The drug helps get rid of acne on the body, but does not eliminate blue spots and scars that remain after mechanical action on inflammatory elements.

Tags: acne

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